Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HAAO | P46952 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31225023 | 0.84 | KDM4E (0.40) | HPGDHTTHAAOCYP1A2CLCN2 | |
| SCHEMBL1671271 | 0.84 | KDM4E (0.40) | HPGDHTTHAAOCYP1A2CLCN2 | |
| SCHEMBL2477973 | 0.84 | HPGD (0.42) | HPGDHTTALDH1A1HDAC3HDAC4 | |
| SCHEMBL27577439 | 0.81 | CYP1A2 (0.44) | HPGDHAAOCYP1A2KDM4EALDH1A1 | |
| SCHEMBL489533 | 0.81 | HPGD (0.55) | HPGDHTTHAAOCYP1A2CLCN2 | |
| SCHEMBL9041660 | 0.80 | HTT (0.43) | HPGDHTTCYP1A2KDM4EALDH1A1 | |
| SCHEMBL7822093 | 0.79 | HPGD (0.44) | HPGDHTTHAAOCYP1A2CLCN2 | |
| SCHEMBL30367318 | 0.79 | HPGD (0.44) | HPGDHTTHAAOCYP1A2CLCN2 | |
| SCHEMBL11285953 | 0.79 | NCEH1 (0.44) | HPGDHAAOCYP1A2KDM4EALDH1A1 | |
| SCHEMBL7558115 | 0.79 | CES2 (0.50) | CYP1A2KDM4EALDH1A1ASPHKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11267804-B2 | (R)-8-(1-((3-fluorophenyl)amino)ethyl)-N-(2-hydroxyethyl)-2-morpholinoquinoxaline-6-carboxamide for inhibiting phosphoinositide-3-kinase activity | JANSSEN PHARMACEUTICA NV (BE) | 2022-03-08 | — | — | US | disclosed |
| EP-3359533-B1 | QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-17 | — | — | EP | disclosed |
| CN-108349946-B | Quinoxaline and pyridopyrazine derivatives as PI3K beta inhibitors | 詹森药业有限公司 | 2021-05-18 | — | — | CN | disclosed |
| CN-107108634-B | Imidazopyridazine derivatives as PI3K beta inhibitors | 詹森药业有限公司 | 2020-09-15 | — | — | CN | disclosed |
| US-20200079763-A1 | QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS A PI3KB INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-03-12 | — | — | US | disclosed |
| CN-106946867-B | FXR receptor modulators and its preparation method and application | 广州市恒诺康医药科技有限公司 | 2019-11-12 | — | — | CN | disclosed |
| EP-3233862-B1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-07-03 | — | — | EP | disclosed |
| US-10087187-B2 | Imidazopyridazine derivatives as PI3KB inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-10-02 | — | — | US | disclosed |
| US-20180002336-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-01-04 | — | — | US | disclosed |
| EP-3233862-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS 3 INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2017-10-25 | — | — | EP | disclosed |
| CN-106946867-A | FXR receptor modulators and its production and use | 广州市恒诺康医药科技有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-106749233-A | One class sulfamide derivative and its application | 中山大学 | 2017-05-31 | — | — | CN | disclosed |
| WO-2017060406-A1 | QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-13 | — | — | WO | disclosed |
| WO-2016097347-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11267804-B2 | (R)-8-(1-((3-fluorophenyl)amino)ethyl)-N-(2-hydroxyethyl)-2-morpholinoquinoxaline-6-carboxamide for inhibiting phosphoinositide-3-kinase activity | PIK3CD, PIK3CA, PIK3CB | HPGD 1293/4885HTT 3676/4885HAAO 1861/4885 |
| US-20180002336-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS | PIK3CB, PIK3CD, PIK3CA | HPGD 1461/4885HTT 3918/4885HAAO 3380/4885 |
| US-20200079763-A1 | QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS A PI3KB INHIBITORS | PIK3CB, PIK3CA, PIK3R5 | HPGD 943/4885HTT 3501/4885HAAO 2079/4885 |
| US-10087187-B2 | Imidazopyridazine derivatives as PI3KB inhibitors | PIK3CB, PIK3CD, PIK3CA | HPGD 1461/4885HTT 3918/4885HAAO 3380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.