SCHEMBL7558115

SCHEMBL7558115

O=C(O)c1ccc(F)c(F)c1Br

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.50
CES1 P23141 3/20 0.50
CYP1A2 P05177 1/20 0.42
MAP2K1 Q02750 2/20 0.41
MAP2K2 P36507 1/20 0.41
ALB P02768 1/20 0.41
BCHE P06276 1/20 0.39
KDM4E B2RXH2 2/20 0.38
ASPH Q12797 1/20 0.38
KDM8 Q8N371 1/20 0.38
DGAT1 O75907 1/20 0.38
TSHR P16473 2/20 0.38
CASP1 P29466 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ALDH1A1 P00352 1/20 0.37
ALOX15 P16050 1/20 0.37
SELL P14151 1/20 0.35
SELP P16109 1/20 0.35
WDR5 P61964 1/20 0.35
GLA P06280 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31094955 0.84 CYP1A2 (0.44) CES2CES1CYP1A2MAP2K1MAP2K2
SCHEMBL318609 0.83 CES2 (0.45) CES2CES1CYP1A2MAP2K1MAP2K2
SCHEMBL29975434 0.83 CES2 (0.45) CES2CES1CYP1A2MAP2K1MAP2K2
SCHEMBL28509492 0.81 SELL (0.48) CYP1A2ALBKDM4ETSHRCASP1
SCHEMBL2827111 0.81 CES2 (0.48) CES2CES1BCHEDGAT1SMN1; SMN2
SCHEMBL25313813 0.81 DGAT1 (0.55) CES2CES1MAP2K1MAP2K2BCHE
SCHEMBL16122327 0.81 CYP1A2 (0.41) CES2CES1CYP1A2MAP2K1MAP2K2
SCHEMBL29741520 0.81 CES2 (0.48) CES2CES1BCHEDGAT1SMN1; SMN2
SCHEMBL241797 0.79 CES2 (0.70) CES2CES1CYP1A2MAP2K1MAP2K2
SCHEMBL7555550 0.79 TSHR (0.44) CES2CES1CYP1A2MAP2K1ALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112138427-B Preparation method of polysubstituted fluorine-containing bromophenol benzoic acid 上海罕道医药科技有限公司 2022-06-24 CN claimed
CN-112138427-A Preparation method of polysubstituted fluorine-containing bromophenol benzoic acid 上海罕道医药科技有限公司 2020-12-29 CN claimed
US-20260109702-A1 NOVEL GSPT PROTEIN DEGRADER AND APPLICATION THEREOF GENOSCO INC (US) 2026-04-23 US disclosed
US-20260109716-A1 CEREBLON-BASED KRAS DEGRADING PROTACS AND USES RELATED THERETO ARVINAS OPERATIONS, INC. (US) 2026-04-23 US disclosed
EP-4720044-A1 AROMATIC AMIDES AND CONJUGATES THEREOF AS BINDERS TO TEAD Beactica Therapeutics AB (SE) 2026-04-08 EP disclosed
EP-4655073-A2 CEREBLON-BASED KRAS DEGRADING PROTACS ANS USES RELATED THERETO Arvinas Operations, Inc. (US) 2025-12-03 EP disclosed
US-12448399-B2 Cereblon-based KRAS degrading PROTACs and uses related thereto ARVINAS OPERATIONS, INC. (US) 2025-10-21 US disclosed
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists BAYER AKTIENGESELLSCHAFT (DE) 2025-08-26 US disclosed
EP-4584258-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2025-07-16 EP disclosed
US-20250161465-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2025-05-22 US disclosed
US-12156916-B2 Rapid accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2024-12-03 US disclosed
WO-2014037480-A1 6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2014-03-13 WO disclosed
WO-2014037480-A1 6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2014-03-13 WO disclosed
EP-0734380-B1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES AVENTIS AGRICULTURE LTD (GB) 2002-07-10 EP disclosed
US-6369270-B1 CHEMICAL INTERMEDIATES RHONE POULENC AGRICULTURE LIMITED (GB) 2002-04-09 US disclosed
US-6114538-A 2-POSITION OF BENZOY RING OF 4-BENZOYLISOXAZOLE DERIVATIVE IS SUBSTITUTED AND PARTICULARLY USED AGAINST MONOCOTYLEDONOUS WEEDS BY POST-EMEREGENECE APPLICATION RHONE POULENC AGRICULTURE LIMITED (GB) 2000-09-05 US disclosed
US-5998653-A CHEMICAL INTERMEDIATE FOR HERBICIDES RHONE POULENC AGRICULTURE LIMITED (GB) 1999-12-07 US disclosed
US-5658858-A POSTEMERGENCE HERBICIDES RHONE-POULENC ARGRICULTURE LIMITED (GB) 1997-08-19 US disclosed
EP-0734380-A1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1996-10-02 EP disclosed
WO-1995016678-A1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE LIMITED (GB) 1995-06-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12448399-B2 Cereblon-based KRAS degrading PROTACs and uses related thereto CRBN, KRAS, WEE1 CES2 4366/4885CES1 2465/4885CYP1A2 4381/4885
US-12156916-B2 Rapid accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use BRAF, ARAF, RAF1 CES2 3454/4885CES1 2284/4885CYP1A2 2531/4885
US-20260109702-A1 NOVEL GSPT PROTEIN DEGRADER AND APPLICATION THEREOF CRBN, PSMB3, PSMB1 CES2 3160/4885CES1 1023/4885CYP1A2 4455/4885
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists ADAMTS7, MMP7, ADAM17 CES2 565/4885CES1 622/4885CYP1A2 3302/4885
US-20250161465-A1 RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE ARAF, BRAF, HRAS CES2 2235/4885CES1 1537/4885CYP1A2 2585/4885
US-20260109716-A1 CEREBLON-BASED KRAS DEGRADING PROTACS AND USES RELATED THERETO KRAS, CRBN, HRAS CES2 3172/4885CES1 1326/4885CYP1A2 4305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.