Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17846108 | 0.77 | MEN1 (0.48) | MEN1KMT2AKDM4CEP300CREBBP | |
| SCHEMBL17845985 | 0.71 | SLC6A3 (0.41) | MEN1KMT2AKDM4CEP300CREBBP | |
| SCHEMBL17835751 | 0.66 | MEN1 (0.43) | MEN1KMT2AKDM4CSLC6A3KDM4E | |
| SCHEMBL17844317 | 0.66 | MEN1 (0.43) | MEN1KMT2AKDM4CSLC6A3KDM4E | |
| SCHEMBL19361667 | 0.66 | MEN1 (0.34) | MEN1KMT2A | |
| SCHEMBL17845968 | 0.66 | SLC6A3 (0.36) | MEN1KMT2AEP300CREBBPSLC6A3 | |
| SCHEMBL7882578 | 0.65 | KDM4C (0.36) | MEN1KMT2AKDM4C | |
| SCHEMBL7882580 | 0.65 | KDM4C (0.36) | MEN1KMT2AKDM4C | |
| SCHEMBL13787407 | 0.65 | KDM4C (0.43) | MEN1KMT2AKDM4CEP300CREBBP | |
| SCHEMBL8985130 | 0.65 | EPHX2 (0.44) | MEN1KMT2AKDM4CCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |