Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306485 | 0.78 | SLC6A3 (0.45) | MEN1KMT2ASLC6A3 | |
| SCHEMBL17845984 | 0.77 | MEN1 (0.38) | MEN1KMT2AKDM4CSLC6A3RAB9A | |
| SCHEMBL7305547 | 0.73 | MEN1 (0.43) | MEN1KMT2AHPGDSLC6A3SMN1; SMN2 | |
| SCHEMBL17846111 | 0.72 | MEN1 (0.48) | MEN1KMT2AKDM4CHPGDSLC6A3 | |
| SCHEMBL21886902 | 0.72 | SLC6A3 (0.53) | MEN1KMT2AKDM4CSLC6A3ADORA3 | |
| SCHEMBL21886901 | 0.71 | MEN1 (0.49) | MEN1KMT2AKDM4CHPGDHTT | |
| SCHEMBL17846125 | 0.71 | MEN1 (0.47) | MEN1KMT2AKDM4CHPGDHTT | |
| SCHEMBL9860360 | 0.70 | MEN1 (0.54) | MEN1KMT2AKDM4CHTTSLC6A3 | |
| SCHEMBL10679283 | 0.70 | MEN1 (0.49) | MEN1KMT2AKDM4CRAB9ANPC1 | |
| SCHEMBL22504269 | 0.69 | KMT2A (0.52) | MEN1KMT2AKDM4CHPGDSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |