Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17846123 | 1.00 | MAPK1 (0.35) | MAPK1CACNA1HCYP19A1PDE2ARPS6KA1 | |
| SCHEMBL20204254 | 1.00 | MAPK1 (0.35) | MAPK1CACNA1HCYP19A1PDE2ARPS6KA1 | |
| SCHEMBL19350254 | 0.92 | GPR139 (0.35) | MAPK1RPS6KA1 | |
| SCHEMBL17846128 | 0.87 | HTR2A (0.36) | MAPK1CACNA1H | |
| SCHEMBL17846047 | 0.87 | HTR2A (0.36) | MAPK1CACNA1H | |
| SCHEMBL20204242 | 0.86 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL17846021 | 0.86 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL17846153 | 0.80 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL20204246 | 0.80 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL20204245 | 0.80 | MAPK1 (0.45) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |