Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097200 | 0.83 | EPHX1 (0.43) | MEN1KMT2AKDM4C | |
| SCHEMBL7330307 | 0.83 | MEN1 (0.39) | MEN1KMT2AKDM4CSLC6A3ALDH1A1 | |
| SCHEMBL13460358 | 0.82 | MEN1 (0.49) | MEN1KMT2AKDM4CLMNA | |
| SCHEMBL17846107 | 0.82 | KDM4C (0.38) | MEN1KMT2AKDM4CSLC6A3ALDH1A1 | |
| SCHEMBL7098095 | 0.81 | KDM4C (0.39) | MEN1KMT2AKDM4CSLC6A3ALDH1A1 | |
| SCHEMBL10433383 | 0.81 | KDM4C (0.39) | MEN1KMT2AKDM4CSLC6A3ALDH1A1 | |
| SCHEMBL7980863 | 0.81 | KDM4C (0.45) | MEN1KMT2AKDM4CALDH1A1 | |
| SCHEMBL10433460 | 0.80 | CREBBP (0.37) | MEN1KMT2AKDM4CSLC6A3ITGB1 | |
| SCHEMBL10433458 | 0.80 | CREBBP (0.37) | MEN1KMT2AKDM4CSLC6A3ITGB1 | |
| SCHEMBL10433401 | 0.80 | KDM4C (0.39) | MEN1KMT2AKDM4CSLC6A3ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |