Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 11/20 | 0.31 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17846150 | 0.77 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL17846115 | 0.67 | MAPK1 (0.36) | MAPK1HASPIN | |
| SCHEMBL17846040 | 0.63 | MAPK1 (0.42) | MAPK1 | |
| SCHEMBL17846059 | 0.62 | HASPIN (0.42) | MAPK1HASPIN | |
| SCHEMBL17848060 | 0.62 | MAPK1 (0.46) | MAPK1HASPIN | |
| SCHEMBL17846026 | 0.61 | HASPIN (0.41) | MAPK1HASPIN | |
| SCHEMBL17846205 | 0.60 | NPC1 (0.39) | MAPK1 | |
| SCHEMBL17846151 | 0.59 | MAPK1 (0.41) | MAPK1HASPIN | |
| SCHEMBL17848008 | 0.58 | HASPIN (0.34) | MAPK1HASPIN | |
| SCHEMBL1230594 | 0.57 | RELA (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233859-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100051-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |