Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 3/20 | 0.31 |
| ▸ | TLR4 | O00206 | 1/20 | 0.30 |
| ▸ | TLR2 | O60603 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17846246 | 1.00 | VCP (0.33) | VCPFBP1TLR4TLR2 | |
| SCHEMBL9115053 | 0.67 | — | — | |
| SCHEMBL4400521 | 0.67 | FBP1 (0.37) | VCPFBP1 | |
| SCHEMBL126472 | 0.66 | — | — | |
| Ammonia Solution, Strong SCHEMBL15667907 | 0.66 | — | — | |
| SCHEMBL11385027 | 0.64 | CYP19A1 (0.33) | VCPFBP1 | |
| SCHEMBL937 | 0.63 | — | — | |
| SCHEMBL22393246 | 0.63 | XPO1 (0.33) | — | |
| SCHEMBL22393247 | 0.63 | XPO1 (0.33) | — | |
| SCHEMBL855683 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095089-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |