Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14762212 | 0.80 | NFE2L2 (0.46) | PTGS1PTGS2TRPA1NFE2L2HSD11B1 | |
| SCHEMBL27986112 | 0.77 | CYP1A2 (0.47) | PTGS1PTGS2 | |
| SCHEMBL17629414 | 0.75 | CYP2C19 (0.41) | LMNA | |
| SCHEMBL28787994 | 0.73 | TYR (0.50) | PTGS1PTGS2LMNA | |
| SCHEMBL28165607 | 0.73 | NFE2L2 (0.40) | PTGS1PTGS2TRPA1NFE2L2HSD11B1 | |
| SCHEMBL5149939 | 0.73 | NFE2L2 (0.37) | NFE2L2 | |
| SCHEMBL27986141 | 0.73 | MAPT (0.42) | LMNATP53 | |
| SCHEMBL9954440 | 0.72 | NFE2L2 (0.44) | PTGS1NFE2L2HSD11B1APP | |
| SCHEMBL8071364 | 0.67 | HSD11B1 (0.52) | HSD11B1LMNA | |
| SCHEMBL29403139 | 0.67 | HSD11B1 (0.57) | HSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3337787-A1 | PYRAZOLO FUSED HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | Changzhou Jiekai Pharmatech Co. Ltd. (CN) | 2018-06-27 | — | — | EP | claimed |
| WO-2017028314-A1 | PYRAZOLO FUSED HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | CHANGZHOU JIEKAI PHARMATECH CO., LTD. (CN) | 2017-02-23 | — | — | WO | claimed |
| EP-3337787-A1 | PYRAZOLO FUSED HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | Changzhou Jiekai Pharmatech Co. Ltd. (CN) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017028314-A1 | PYRAZOLO FUSED HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | CHANGZHOU JIEKAI PHARMATECH CO., LTD. (CN) | 2017-02-23 | — | — | WO | disclosed |
| WO-2016095089-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |