Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | SMO | Q99835 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16463843 | 0.86 | TP53 (0.58) | L3MBTL1MAPK1SMOALDH1A1MAPT | |
| SCHEMBL16460666 | 0.82 | P2RX7 (0.67) | ALDH1A1P2RX7 | |
| SCHEMBL21338393 | 0.80 | L3MBTL1 (0.53) | L3MBTL1MAPK1SMOALDH1A1KDM4E | |
| SCHEMBL16461650 | 0.80 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL16461469 | 0.80 | P2RX7 (0.72) | ALDH1A1P2RX7 | |
| SCHEMBL16461215 | 0.79 | DPP4 (0.56) | L3MBTL1MAPK1SMOALDH1A1KDM4E | |
| SCHEMBL16373543 | 0.79 | SMN1; SMN2 (0.50) | L3MBTL1MAPK1SMOALDH1A1MAPT | |
| SCHEMBL16461068 | 0.77 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL30275033 | 0.77 | L3MBTL1 (0.47) | L3MBTL1CYP3A4CYP2C19ALDH1A1KDM4E | |
| SCHEMBL1991270 | 0.76 | POLB (0.51) | L3MBTL1MAPK1SMOALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095089-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | claimed |