Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TAS2R46 | P59540 | 6/20 | 0.33 |
| ▸ | TAS2R31 | P59538 | 2/20 | 0.33 |
| ▸ | TAS2R10 | Q9NYW0 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28183790 | 0.95 | LMNA (0.44) | LMNANPC1ALDH1A1TSHRRAB9A | |
| SCHEMBL16796012 | 0.90 | LMNA (0.44) | LMNATAS2R46TAS2R31TAS2R10PTPN1 | |
| SCHEMBL6882235 | 0.90 | LMNA (0.44) | LMNATAS2R46TAS2R31TAS2R10PTPN1 | |
| SCHEMBL736990 | 0.90 | LMNA (0.44) | LMNATAS2R46TAS2R31TAS2R10PTPN1 | |
| SCHEMBL5933973 | 0.90 | LMNA (0.44) | LMNATAS2R46TAS2R31TAS2R10PTPN1 | |
| SCHEMBL3851126 | 0.90 | LMNA (0.44) | LMNATAS2R46TAS2R31TAS2R10PTPN1 | |
| SCHEMBL14528164 | 0.84 | LMNA (0.41) | LMNANPC1ALDH1A1TSHRRAB9A | |
| SCHEMBL8813386 | 0.80 | LMNA (0.37) | LMNATAS2R46TAS2R31TAS2R10PTPN1 | |
| SCHEMBL11309572 | 0.80 | LMNA (0.41) | LMNANPC1ALDH1A1TSHRRAB9A | |
| SCHEMBL6402023 | 0.79 | LMNA (0.46) | LMNANPC1ALDH1A1TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233868-B1 | 6H-PYRROLO[3,2-B:4,5-B']BIS[1,4]BENZOTHIAZINE-6-CARBOXYLIC ACID ESTERS AS ORGANIC SEMICONDUCTOR MATERIALS FOR USE IN ELECTRONIC DEVICES | BASF SE (DE) | 2018-11-07 | — | — | EP | disclosed |
| US-10079346-B2 | Heteroaromatic compounds for organic electronics | BASF SE (DE) | 2018-09-18 | — | — | US | disclosed |
| US-20170365791-A1 | HETEROAROMATIC COMPOUNDS FOR ORGANIC ELECTRONICS | BASF SE (DE) | 2017-12-21 | — | — | US | disclosed |
| EP-3233868-A1 | 6H-PYRROLO[3,2-B:4,5-B']BIS[1,4]BENZOTHIAZINE-6-CARBOXYLIC ACID ESTERS AS ORGANIC SEMICONDUCTOR MATERIALS FOR USE IN ELECTRONIC DEVICES | BASF SE (DE) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096967-A1 | 6H-PYRROLO[3,2-B:4,5-B']BIS[1,4]BENZOTHIAZINE-6-CARBOXYLIC ACID ESTERS AS ORGANIC SEMICONDUCTOR MATERIALS FOR USE IN ELECTRONIC DEVICES | BASF SE (DE) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10079346-B2 | Heteroaromatic compounds for organic electronics | OR10J3, OR51E2, OXER1 | LMNA 3332/4885NPC1 810/4885ALDH1A1 1250/4885 |
| US-20170365791-A1 | HETEROAROMATIC COMPOUNDS FOR ORGANIC ELECTRONICS | OR10J3, NR0B1, NR0B2 | LMNA 2964/4885NPC1 718/4885ALDH1A1 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.