Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL93800 | 0.87 | LMNA (0.67) | BLMLMNAPTPN1MEN1CYP3A4 | |
| SCHEMBL19392377 | 0.87 | LMNA (0.67) | BLMLMNAPTPN1MEN1CYP3A4 | |
| Hexane SCHEMBL8373837 | 0.86 | ACE2 (0.52) | BLMLMNAACE2CA2MAPK1 | |
| Hypochlorous Acid SCHEMBL11411029 | 0.85 | LMNA (0.57) | BLMLMNAACE2PTPN1MEN1 | |
| SCHEMBL29843605 | 0.85 | LMNA (0.72) | BLMLMNAACE2PTPN1MEN1 | |
| SCHEMBL149808 | 0.85 | LMNA (0.72) | BLMLMNAACE2PTPN1MEN1 | |
| SCHEMBL1269942 | 0.85 | LMNA (0.72) | BLMLMNAACE2PTPN1MEN1 | |
| SCHEMBL28724453 | 0.85 | LMNA (0.72) | BLMLMNAACE2PTPN1MEN1 | |
| Methane SCHEMBL28255959 | 0.85 | LMNA (0.63) | BLMLMNAPTPN1MEN1CYP3A4 | |
| Bicarbonate SCHEMBL10599024 | 0.84 | BLM (0.63) | BLMLMNAACE2PTPN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233868-B1 | 6H-PYRROLO[3,2-B:4,5-B']BIS[1,4]BENZOTHIAZINE-6-CARBOXYLIC ACID ESTERS AS ORGANIC SEMICONDUCTOR MATERIALS FOR USE IN ELECTRONIC DEVICES | BASF SE (DE) | 2018-11-07 | — | — | EP | disclosed |
| US-10079346-B2 | Heteroaromatic compounds for organic electronics | BASF SE (DE) | 2018-09-18 | — | — | US | disclosed |
| US-20170365791-A1 | HETEROAROMATIC COMPOUNDS FOR ORGANIC ELECTRONICS | BASF SE (DE) | 2017-12-21 | — | — | US | disclosed |
| EP-3233868-A1 | 6H-PYRROLO[3,2-B:4,5-B']BIS[1,4]BENZOTHIAZINE-6-CARBOXYLIC ACID ESTERS AS ORGANIC SEMICONDUCTOR MATERIALS FOR USE IN ELECTRONIC DEVICES | BASF SE (DE) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096967-A1 | 6H-PYRROLO[3,2-B:4,5-B']BIS[1,4]BENZOTHIAZINE-6-CARBOXYLIC ACID ESTERS AS ORGANIC SEMICONDUCTOR MATERIALS FOR USE IN ELECTRONIC DEVICES | BASF SE (DE) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10079346-B2 | Heteroaromatic compounds for organic electronics | OR10J3, OR51E2, OXER1 | BLM 2349/4885LMNA 3332/4885ACE2 2711/4885 |
| US-20170365791-A1 | HETEROAROMATIC COMPOUNDS FOR ORGANIC ELECTRONICS | OR10J3, NR0B1, NR0B2 | BLM 2258/4885LMNA 2964/4885ACE2 2281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.