SCHEMBL17847307

SCHEMBL17847307

Nc1nc2c(C(F)(F)F)cccc2n1-c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 13/20 0.45
NR1H3 Q13133 13/20 0.45
CNR1 P21554 1/20 0.39
CNR2 P34972 1/20 0.39
GRM2 Q14416 1/20 0.39
HCAR1 Q9BXC0 1/20 0.39
MDM2 Q00987 1/20 0.38
MAPK1 P28482 1/20 0.38
HTT P42858 1/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30822925 0.84 NR1H2 (0.41) NR1H2NR1H3GRM2
SCHEMBL900719 0.83 NR1H2 (0.58) NR1H2NR1H3CNR1CNR2MDM2
SCHEMBL21555501 0.78 HSD11B1 (0.41) GRM2
SCHEMBL1271771 0.73 NR1H2 (0.47) NR1H2NR1H3MEN1KMT2A
SCHEMBL6272353 0.72 ALDH1A1 (0.44) HCAR1MAPK1HTTMEN1KMT2A
SCHEMBL30248988 0.72 PARP1 (0.54) MAPK1MEN1KMT2A
SCHEMBL12900966 0.72 NR1H2 (0.74) NR1H2NR1H3
SCHEMBL1271026 0.71 NR1H2 (0.56) NR1H2NR1H3HTTMEN1KMT2A
SCHEMBL1272181 0.71 NR1H2 (0.56) NR1H2NR1H3MAPK1
SCHEMBL1272108 0.71 NR1H2 (0.52) NR1H2NR1H3CNR1CNR2MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4565566-A1 SUBSTITUTED BENZIMIDAZOLES FOR TREATING VIRAL DISEASES Council of Scientific and Industrial Research, an Indian Registered Body Incorporated under Regn. of Soc. Act (Act XXI of 1860) (IN) 2025-06-11 EP disclosed
WO-2024028893-A1 SUBSTITUTED BENZIMIDAZOLES FOR TREATING VIRAL DISEASES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN. OF SOC. ACT (ACT XXI OF 1860) (IN) 2024-02-08 WO disclosed
EP-4313144-A1 COMBINATIONS COMPRISING ANTI-TM4SF1 ANTIBODIES AND IMMUNOTHERAPEUTIC AGENTS AND METHODS OF USING THE SAME Angiex, Inc. (US) 2024-02-07 EP disclosed
EP-4211230-A1 COMPOSITIONS AND METHODS FOR T CELL ENGINEERING Gracell Biotechnologies (Shanghai) Co., Ltd. (CN) 2023-07-19 EP disclosed
WO-2022204565-A1 COMBINATIONS COMPRISING ANTI-TM4SF1 ANTIBODIES AND IMMUNOTHERAPEUTIC AGENTS AND METHODS OF USING THE SAME ANGIEX, INC. (US) 2022-09-29 WO disclosed
EP-4041725-A1 QUINOLINE COMPOUNDS AND COMPOSITIONS FOR INHIBITING EZH2 Novartis AG (CH) 2022-08-17 EP disclosed
WO-2022052913-A1 COMPOSITIONS AND METHODS FOR T CELL ENGINEERING GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD. (CN) 2022-03-17 WO disclosed
WO-2022033492-A1 QUINOLINE COMPOUNDS AND COMPOSITIONS FOR INHIBITING EZH2 NOVARTIS AG (CH) 2022-02-17 WO disclosed
WO-2021223359-A1 COMPOSITIONS AND METHODS FOR T CELL ENGINEERING GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD. (CN) 2021-11-11 WO disclosed
WO-2021223705-A1 COMPOSITIONS AND METHODS FOR T CELL ENGINEERING GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD. (CN) 2021-11-11 WO disclosed
EP-3874030-A1 COMPOSITIONS AND METHODS FOR T CELL ENGINEERING Gracell Biotechnologies (Shanghai) Co., Ltd. (CN) 2021-09-08 EP disclosed
EP-3523290-A1 IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY Novartis AG (CH) 2019-08-14 EP disclosed
EP-3397756-A1 IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY Novartis AG (CH) 2018-11-07 EP disclosed
WO-2018059549-A1 IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY NOVARTIS AG (CH) 2018-04-05 WO disclosed
EP-3233918-A1 COMBINATION THERAPIES Novartis AG (CH) 2017-10-25 EP disclosed
WO-2017114497-A1 IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY NOVARTIS AG (CH) 2017-07-06 WO disclosed
WO-2016100882-A1 COMBINATION THERAPIES NOVARTIS AG (CH) 2016-06-23 WO disclosed