Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 10/20 | 0.58 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.49 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racemethionine SCHEMBL17847431 | 1.00 | BHMT (0.58) | BHMTBHMT2RNPEPSLC1A3SLC1A2 | |
| Methionine SCHEMBL108277 | 0.95 | BHMT (0.59) | BHMTBHMT2RNPEPSLC1A3SLC1A2 | |
| Methionine SCHEMBL1955009 | 0.95 | BHMT (0.59) | BHMTBHMT2RNPEPSLC1A3SLC1A2 | |
| Racemethionine SCHEMBL108276 | 0.95 | BHMT (0.59) | BHMTBHMT2RNPEPSLC1A3SLC1A2 | |
| Racemethionine SCHEMBL8954847 | 0.93 | BHMT (0.57) | BHMTBHMT2RNPEPSLC1A3SLC1A2 | |
| Methionine SCHEMBL8954852 | 0.93 | BHMT (0.57) | BHMTBHMT2RNPEPSLC1A3SLC1A2 | |
| Racemethionine SCHEMBL2804076 | 0.91 | BHMT (0.56) | BHMTBHMT2RNPEPSLC1A3SLC1A2 | |
| Methionine SCHEMBL1163783 | 0.91 | BHMT (0.56) | BHMTBHMT2RNPEPSLC1A3SLC1A2 | |
| Methionine SCHEMBL14485913 | 0.91 | BHMT (0.56) | BHMTBHMT2RNPEPSLC1A3SLC1A2 | |
| Racemethionine SCHEMBL1163782 | 0.91 | BHMT (0.56) | BHMTBHMT2RNPEPSLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016098757-A1 | METHOD FOR DETECTING AMINO ACIDS OR ACYLCARNITINE | 積水メディカル株式会社 | 2016-06-23 | — | — | WO | disclosed |