Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17847436 | 0.88 | SMN1; SMN2 (0.50) | HPGDGPR35ALDH1A1KDM4ETDP1 | |
| SCHEMBL2438825 | 0.84 | HPGD (0.47) | HPGDGPR35ALDH1A1KDM4ETDP1 | |
| SCHEMBL30106402 | 0.84 | ALDH1A1 (0.53) | HPGDGPR35ALDH1A1KDM4ETDP1 | |
| SCHEMBL11497260 | 0.77 | HPGD (0.62) | HPGDGPR35ALDH1A1TDP1NPC1 | |
| SCHEMBL28931147 | 0.75 | HPGD (0.45) | HPGDGPR35ALDH1A1KDM4ETDP1 | |
| SCHEMBL2496089 | 0.74 | TDP1 (0.67) | HPGDALDH1A1KDM4ETDP1NPC1 | |
| SCHEMBL28637817 | 0.73 | TDP1 (0.50) | HPGDGPR35TDP1MEN1TTR | |
| SCHEMBL10499773 | 0.72 | ALDH1A1 (0.46) | HPGDGPR35ALDH1A1KDM4ETDP1 | |
| SCHEMBL28938591 | 0.72 | PHGDH (0.42) | GPR35ALDH1A1TDP1NPC1RAB9A | |
| SCHEMBL14372522 | 0.72 | HPGD (0.45) | HPGDGPR35ALDH1A1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3474863-A1 | PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS | Emory University (US) | 2019-05-01 | — | — | EP | disclosed |
| WO-2017223421-A1 | PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS | EMORY UNIVERSITY (US) | 2017-12-28 | — | — | WO | disclosed |
| EP-3233878-A2 | PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS | Emory University (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016099982-A2 | PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS | EMORY UNIVERSITY (US) | 2016-06-23 | — | — | WO | disclosed |