Sugi Predict

Sugi Predict / Compounds / SCHEMBL2496089

SCHEMBL2496089

SCHEMBL2496089

COc1cccc([N+](=O)[O-])c1Cl

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 4/20 0.67
▸ ALDH1A1 P00352 2/20 0.67
▸ L3MBTL1 Q9Y468 2/20 0.59
▸ HPGD P15428 1/20 0.50
▸ PIN1 Q13526 1/20 0.49
▸ G6PD P11413 1/20 0.47
▸ CRHBP P24387 1/20 0.47
▸ CRHR2 Q13324 1/20 0.47
▸ KMT2A Q03164 3/20 0.46
▸ NPC1 O15118 3/20 0.46
▸ RAB9A P51151 3/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ RECQL P46063 1/20 0.46
▸ LMNA P02545 2/20 0.46
▸ MEN1 O00255 2/20 0.46
▸ MAPT P10636 2/20 0.45
▸ KDM4E B2RXH2 1/20 0.45
▸ ALOX12 P18054 1/20 0.45
▸ MAPK1 P28482 3/20 0.44
▸ AR P10275 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethoxycarbonyl Group SCHEMBL25297351 0.85 ALDH1A1 (0.50) TDP1ALDH1A1L3MBTL1HPGDPIN1
SCHEMBL11497260 0.85 HPGD (0.62) TDP1ALDH1A1L3MBTL1HPGDKMT2A
SCHEMBL31503717 0.83 TDP1 (0.57) TDP1ALDH1A1L3MBTL1PIN1G6PD
SCHEMBL4980012 0.83 TDP1 (0.57) TDP1ALDH1A1L3MBTL1PIN1G6PD
SCHEMBL2088309 0.81 TDP1 (0.71) TDP1ALDH1A1L3MBTL1HPGDKMT2A
SCHEMBL1161927 0.81 TDP1 (0.71) TDP1ALDH1A1L3MBTL1KMT2ANPC1
SCHEMBL31119225 0.81 TDP1 (0.71) TDP1ALDH1A1L3MBTL1HPGDKMT2A
SCHEMBL31119224 0.81 TDP1 (0.71) TDP1ALDH1A1L3MBTL1HPGDKMT2A
SCHEMBL7159716 0.81 ALDH1A1 (0.71) TDP1ALDH1A1L3MBTL1KMT2ANPC1
SCHEMBL29603881 0.81 TDP1 (0.71) TDP1ALDH1A1L3MBTL1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1016405-A2 Arylating medicaments Radopath Pharmaceuticals International Limited (GB) 2000-07-05 — — EP claimed
EP-0700287-A1 ARYLATING MEDICAMENTS RADOPATH LIMITED (GB) 1996-03-13 — — EP claimed
WO-1994027584-A2 ARYLATING MEDICAMENTS RADOPATH LIMITED (GB) 1994-12-08 — — WO claimed
WO-2025038863-A1 INDOLE AND PYRROLOYPYRIDINE DERIVATIVES AS GPR17 MODULATORS BIOGEN MA INC. (US) 2025-02-20 — — WO disclosed
CN-111848598-B Heterocyclic compound, application thereof and composition containing same 健艾仕生物医药有限公司 2024-12-10 — — CN disclosed
US-12071404-B2 Aza (indole)-, benzothiophene-, and benzofuran-3-sulfonamides UCB PHARMA GMBH (DE) 2024-08-27 — — US disclosed
CN-117362642-A Polyimide with high Tg and low dielectric constant, and preparation method and application thereof 中国科学院福建物质结构研究所 2024-01-09 — — CN disclosed
US-11820746-B2 Aza (indole)-, benzothiophene-, and benzofuran-3-sulfonamides UCB PHARMA GMBH (DE) 2023-11-21 — — US disclosed
US-11820746-B2 Aza (indole)-, benzothiophene-, and benzofuran-3-sulfonamides UCB PHARMA GMBH (DE) 2023-11-21 — — US disclosed
US-20230348384-A1 Aza (Indole)-, Benzothiophene-, And Benzofuran-3-Sulfonamides UCB PHARMA GMBH (DE) 2023-11-02 — — US disclosed
US-20230348384-A1 Aza (Indole)-, Benzothiophene-, And Benzofuran-3-Sulfonamides UCB PHARMA GMBH (DE) 2023-11-02 — — US disclosed
EP-0512817-A1 Pyridazinedione derivatives, their preparation and pharmaceutical applications ZENECA LIMITED (GB) 1992-11-11 — — EP disclosed
EP-0076220-B1 PROCESS FOR THE HYDROLYSIS OF ARYL ALIPHATIC ETHERS RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1985-08-07 — — EP disclosed
EP-0076220-A1 Process for the hydrolysis of aryl aliphatic ethers RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1983-04-06 — — EP disclosed
US-4224248-A Process for the depyrophorization of pyrophoric metal catalysts and uses thereof BAYER AKTIENGESELLSCHAFT (DE) 1980-09-23 — — US disclosed
US-4224340-A Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds WILLIAM H. RORER, INC. (US) 1980-09-23 — — US disclosed
US-4214003-A ANTIINFLAMMATORY AGENTS WILLIAM H. RORER, INC. (US) 1980-07-22 — — US disclosed
US-4197314-A WITH A DIPHENYL NITRONE WILLIAM H. RORER, INC. (US) 1980-04-08 — — US disclosed
US-4176092-A TREATMENT WITH AN ORGANIC NITRO OR A NITROSO COMPOUND BAYER AKTIENGESELLSCHAFT (DE) 1979-11-27 — — US disclosed
US-4153722-A ANTIINFLAMMATORY, A-PHENYL-N-PHENYLNITRONE WILLIAM H. RORER, INC. (US) 1979-05-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11820746-B2 Aza (indole)-, benzothiophene-, and benzofuran-3-sulfonamides GPR17, GPR18, GPR27 TDP1 2989/4885ALDH1A1 1065/4885L3MBTL1 4599/4885
US-20230348384-A1 Aza (Indole)-, Benzothiophene-, And Benzofuran-3-Sulfonamides GPR17, GPR18, GPR27 TDP1 2989/4885ALDH1A1 1065/4885L3MBTL1 4599/4885
US-12071404-B2 Aza (indole)-, benzothiophene-, and benzofuran-3-sulfonamides GPR17, GPR18, GPR27 TDP1 2989/4885ALDH1A1 1065/4885L3MBTL1 4599/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.