Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 15/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3071688 | 0.84 | HDAC3 (0.64) | HDAC1HDAC3HDAC2MAPK1HDAC6 | |
| SCHEMBL31174164 | 0.84 | HDAC3 (0.64) | HDAC1HDAC3HDAC2MAPK1HDAC6 | |
| SCHEMBL13068319 | 0.83 | HDAC3 (0.55) | HDAC1HDAC3HDAC2MAPK1HDAC6 | |
| SCHEMBL15938389 | 0.81 | HDAC1 (0.53) | HDAC1HDAC3HDAC2MAPK1HDAC6 | |
| SCHEMBL8001493 | 0.81 | HDAC1 (0.53) | HDAC1HDAC3HDAC2MAPK1HDAC6 | |
| SCHEMBL29642005 | 0.81 | HDAC1 (0.53) | HDAC1HDAC3HDAC2MAPK1HDAC6 | |
| SCHEMBL20040512 | 0.80 | HDAC1 (0.50) | HDAC1HDAC3HDAC2MAPK1HDAC6 | |
| SCHEMBL21007304 | 0.80 | HDAC1 (0.60) | HDAC1HDAC3HDAC2MAPK1HDAC6 | |
| SCHEMBL9797986 | 0.80 | HDAC3 (0.56) | HDAC1HDAC3HDAC2MAPK1HDAC6 | |
| SCHEMBL11048016 | 0.79 | HDAC3 (0.63) | HDAC1HDAC3HDAC2MAPK1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100452-A2 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |