SCHEMBL17847702

SCHEMBL17847702

COC(=O)Cc1ccc(-c2ccc(F)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.58
MEN1 O00255 2/20 0.58
CYP4F2 P78329 1/20 0.58
CYP4A11 Q02928 1/20 0.58
SMN1; SMN2 Q16637 4/20 0.54
KLK7 P49862 2/20 0.50
GAA P10253 4/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
MAPK1 P28482 1/20 0.49
ALDH1A1 P00352 2/20 0.48
MAPT P10636 1/20 0.48
CA12 O43570 1/20 0.48
CA2 P00918 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
GFER P55789 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
HSP90AB1 P08238 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL378218 0.94 CYP4F2 (0.63) KMT2AMEN1CYP4F2CYP4A11SMN1; SMN2
SCHEMBL17070607 0.94 CYP4F2 (0.63) KMT2AMEN1CYP4F2CYP4A11SMN1; SMN2
Nitrogen SCHEMBL27904011 0.91 KMT2A (0.60) KMT2AMEN1CYP4F2CYP4A11SMN1; SMN2
SCHEMBL7558146 0.86 KMT2A (0.56) KMT2AMEN1CYP4F2CYP4A11SMN1; SMN2
SCHEMBL31324158 0.86 MEN1 (0.63) KMT2AMEN1CYP4F2CYP4A11SMN1; SMN2
SCHEMBL4113212 0.84 CYP4F2 (0.76) KMT2ACYP4F2CYP4A11SMN1; SMN2GAA
SCHEMBL1428025 0.83 LMNA (0.62) KMT2AMEN1CYP4F2CYP4A11SMN1; SMN2
SCHEMBL15804409 0.83 CYP4F2 (0.59) KMT2AMEN1CYP4F2CYP4A11SMN1; SMN2
SCHEMBL6301861 0.83 CYP4F2 (0.59) KMT2ACYP4F2CYP4A11SMN1; SMN2GAA
SCHEMBL24399521 0.82 CYP4F2 (0.51) KMT2AMEN1CYP4F2CYP4A11SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3234067-B1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2018-08-22 EP disclosed
US-20180022996-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2018-01-25 US disclosed
US-20180022996-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2018-01-25 US disclosed
US-20180022996-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2018-01-25 US disclosed
EP-3234067-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA Merck Patent GmbH (DE) 2017-10-25 EP disclosed
WO-2016096082-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2016-06-23 WO disclosed
WO-2016096082-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2016-06-23 WO disclosed