Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | SGK1 | O00141 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848114 | 0.91 | SGK1 (0.46) | MPOSGK1FGFR1ABL1GSK3B | |
| SCHEMBL17848411 | 0.85 | MPO (0.37) | MPOSGK1ABL1BCRMAP2K4 | |
| SCHEMBL20560056 | 0.84 | MKNK1 (0.47) | MPOFGFR1ABL1GSK3BDAPK3 | |
| SCHEMBL17848143 | 0.84 | FGFR1 (0.43) | FGFR1ABL1GSK3BDAPK3PRKD3 | |
| SCHEMBL17848203 | 0.83 | FGFR1 (0.45) | MPOFGFR1ABL1GSK3BDAPK3 | |
| SCHEMBL17848199 | 0.78 | JAK2 (0.47) | FGFR1GSK3BMETFGFR2FGFR3 | |
| SCHEMBL17848129 | 0.77 | MAP2K4 (0.45) | FGFR1ABL1GSK3BBCRFGFR2 | |
| SCHEMBL17848152 | 0.77 | JAK2 (0.44) | SGK1FGFR1GSK3BKDRFGFR2 | |
| SCHEMBL17848181 | 0.77 | JAK2 (0.43) | FGFR1GSK3BDAPK3PRKACAKDR | |
| SCHEMBL20560052 | 0.76 | SGK1 (0.39) | MPOSGK1ABL1NTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233840-B1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S R L (IT) | 2018-11-21 | — | — | EP | claimed |
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | claimed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | claimed |
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |