Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848143 | 0.86 | FGFR1 (0.43) | JAK2FGFR1FGFR2FGFR3MKNK1 | |
| SCHEMBL20559532 | 0.84 | JAK2 (0.37) | JAK2FGFR1FGFR2FGFR3JAK3 | |
| SCHEMBL17848152 | 0.84 | JAK2 (0.44) | JAK2FGFR1FGFR2FGFR3JAK3 | |
| SCHEMBL17848199 | 0.82 | JAK2 (0.47) | JAK2FGFR1FGFR2FGFR3JAK3 | |
| SCHEMBL20560056 | 0.81 | MKNK1 (0.47) | JAK2FGFR1FGFR2FGFR3MKNK1 | |
| SCHEMBL17848114 | 0.79 | SGK1 (0.46) | JAK2FGFR1FGFR2FGFR3MKNK1 | |
| SCHEMBL17848203 | 0.78 | FGFR1 (0.45) | JAK2FGFR1FGFR2FGFR3MKNK1 | |
| SCHEMBL6489615 | 0.77 | PDPK1 (0.53) | JAK2FGFR1FGFR2FGFR3JAK3 | |
| SCHEMBL17848150 | 0.77 | MPO (0.40) | JAK2FGFR1FGFR2FGFR3PDPK1 | |
| SCHEMBL17848129 | 0.77 | MAP2K4 (0.45) | JAK2FGFR1FGFR2FGFR3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233840-B1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S R L (IT) | 2018-11-21 | — | — | EP | claimed |
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | claimed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | claimed |
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |