Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | GAK | O14976 | 2/20 | 0.42 |
| ▸ | STK16 | O75716 | 2/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | BMP2K | Q9NSY1 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848223 | 0.91 | NTRK1 (0.51) | DYRK1ANTRK1PARP1GSK3BPLK4 | |
| SCHEMBL17848290 | 0.77 | PARP1 (0.37) | DYRK1ANTRK1PARP1MAPK1GAK | |
| SCHEMBL17848108 | 0.77 | MAPK1 (0.47) | DYRK1ANTRK1MAPK1CDK1CDK2 | |
| SCHEMBL3510459 | 0.76 | NTRK1 (0.77) | NTRK1PLK4AURKADAPK3PRKCG | |
| SCHEMBL590945 | 0.72 | ABCC9 (0.47) | DYRK1ANTRK1GAKCDK1CDK4 | |
| SCHEMBL17848098 | 0.71 | DYRK1A (0.85) | DYRK1AGSK3BPDPK1JAK2 | |
| SCHEMBL6855281 | 0.71 | DYRK1A (0.67) | DYRK1ANTRK1CDK1CDK4CDK2 | |
| SCHEMBL17848094 | 0.69 | NTRK1 (0.39) | DYRK1ANTRK1PARP1GSK3BAURKA | |
| SCHEMBL17848139 | 0.68 | GSK3B (0.47) | DYRK1ANTRK1MAPK1GSK3BPLK4 | |
| SCHEMBL17859076 | 0.68 | MPO (0.34) | HCAR2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |