Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 4/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.52 |
| ▸ | AURKA | O14965 | 4/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 9/20 | 0.44 |
| ▸ | FLT3 | P36888 | 8/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848097 | 0.88 | AURKA (0.49) | INSRALKAURKANTRK1IGF1R | |
| SCHEMBL20102203 | 0.83 | ALK (0.45) | INSRALKAURKANTRK1IGF1R | |
| SCHEMBL17848096 | 0.82 | ALK (0.44) | INSRALKAURKANTRK1IGF1R | |
| SCHEMBL589615 | 0.79 | IGF1R (0.48) | INSRALKAURKANTRK1IGF1R | |
| SCHEMBL20102209 | 0.79 | ALK (0.48) | INSRALKAURKANTRK1IGF1R | |
| SCHEMBL17848113 | 0.78 | ALK (0.40) | INSRALKAURKANTRK1IGF1R | |
| SCHEMBL17848119 | 0.78 | ALK (0.47) | INSRALKAURKANTRK1IGF1R | |
| SCHEMBL3511630 | 0.78 | ALK (0.66) | INSRALKAURKANTRK1IGF1R | |
| SCHEMBL3513579 | 0.75 | ALK (0.53) | INSRALKAURKANTRK1IGF1R | |
| SCHEMBL17848267 | 0.75 | INSR (0.57) | INSRALKAURKANTRK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336707-B2 | Heterocyclic derivatives modulating activity of certain protein kinases | EUDENDRON S.R.L. (IT) | 2019-07-02 | — | — | US | disclosed |
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | UNVERSITA' DEGLI STUDI DI MILANO (IT) | 2018-05-03 | — | — | US | disclosed |
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | UNVERSITA' DEGLI STUDI DI MILANO (IT) | 2018-05-03 | — | — | US | disclosed |
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | MAP4K2, MAP3K20, MAPKAPK2 | INSR 2001/4885ALK 2551/4885AURKA 552/4885 |
| US-10336707-B2 | Heterocyclic derivatives modulating activity of certain protein kinases | MAP4K2, MAP3K20, MAPKAPK2 | INSR 2001/4885ALK 2551/4885AURKA 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.