Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.40 |
| ▸ | INSR | P06213 | 18/20 | 0.40 |
| ▸ | IGF1R | P08069 | 10/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | PRKCG | P05129 | 2/20 | 0.38 |
| ▸ | ROS1 | P08922 | 2/20 | 0.38 |
| ▸ | FER | P16591 | 2/20 | 0.38 |
| ▸ | LTK | P29376 | 2/20 | 0.38 |
| ▸ | FRK | P42685 | 2/20 | 0.38 |
| ▸ | MST1R | Q04912 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848119 | 0.86 | ALK (0.47) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL20102209 | 0.82 | ALK (0.48) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL590573 | 0.81 | ALK (0.39) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL17848096 | 0.81 | ALK (0.44) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL20110107 | 0.80 | ALK (0.34) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL17848247 | 0.78 | INSR (0.52) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL20102203 | 0.78 | ALK (0.45) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL17848325 | 0.75 | ALK (0.51) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL1890972 | 0.75 | IGF1R (0.47) | ALKINSRIGF1RAURKAAURKB | |
| SCHEMBL20102212 | 0.74 | HTR6 (0.35) | ALKINSRIGF1RAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | disclosed |