Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 13/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848942 | 0.80 | PSEN1 (0.33) | RBP4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28469141 | 0.69 | PSEN1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23070565 | 0.67 | SSTR4 (0.31) | — | |
| SCHEMBL17353258 | 0.66 | PDE4D (0.40) | RBP4 | |
| SCHEMBL19423469 | 0.64 | PDE4D (0.41) | RBP4 | |
| SCHEMBL17920816 | 0.64 | PDE4D (0.41) | RBP4 | |
| SCHEMBL17353008 | 0.64 | PDE4D (0.41) | RBP4 | |
| SCHEMBL23070667 | 0.63 | SSTR4 (0.34) | — | |
| SCHEMBL23070652 | 0.63 | JAK2 (0.33) | — | |
| SCHEMBL23070668 | 0.63 | JAK2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233863-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG Pharmaceutical Co., Ltd. (KR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097869-A1 | FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS | CMG PHARMACEUTICAL CO., LTD. (KR) | 2016-06-23 | — | — | WO | disclosed |