Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23070668 | 1.00 | JAK2 (0.33) | JAK2NTRK1SSTR4MAP3K14 | |
| SCHEMBL23070667 | 0.89 | SSTR4 (0.34) | SSTR4MAP3K14 | |
| SCHEMBL23070565 | 0.86 | SSTR4 (0.31) | SSTR4 | |
| SCHEMBL17060748 | 0.71 | CCR2 (0.41) | — | |
| SCHEMBL23149434 | 0.69 | SSTR4 (0.30) | SSTR4 | |
| SCHEMBL17920816 | 0.69 | PDE4D (0.41) | NTRK1 | |
| SCHEMBL17353008 | 0.69 | PDE4D (0.41) | NTRK1 | |
| SCHEMBL21408257 | 0.68 | POLQ (0.35) | SSTR4 | |
| SCHEMBL30433944 | 0.68 | POLQ (0.35) | SSTR4 | |
| SCHEMBL4976260 | 0.68 | SLC6A2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021042890-A1 | HETEROCYCLIC COMPOUND AND APPLICATION THEREOF AS TRK KINASE INHIBITOR | 罗欣药业(上海)有限公司 | 2021-03-11 | — | — | WO | disclosed |