Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17830897 | 0.77 | PSEN1 (0.38) | PSEN1APPHTR1AADRA2ADRD2 | |
| SCHEMBL1429735 | 0.74 | PSEN1 (0.42) | PSEN1APPHTR1AADRA2ADRD2 | |
| SCHEMBL17353253 | 0.73 | PSEN1 (0.42) | PSEN1APPHTR1AADRA2ADRD2 | |
| SCHEMBL21136075 | 0.72 | RORC (0.42) | PSEN1APPHTR1AADRA2ADRD2 | |
| SCHEMBL20119114 | 0.72 | PSEN1 (0.36) | PSEN1APPHTR1AADRA2ADRD2 | |
| SCHEMBL23327641 | 0.71 | HSD11B1 (0.43) | PSEN1APPHTR1AADRA2ADRD2 | |
| SCHEMBL29891503 | 0.71 | PSEN1 (0.41) | PSEN1APPHTR1AADRA2ADRD2 | |
| SCHEMBL21136665 | 0.71 | PSEN1 (0.41) | PSEN1APPHTR1AADRA2ADRD2 | |
| SCHEMBL26465788 | 0.71 | PSEN1 (0.41) | PSEN1APPHTR1AADRA2ADRD2 | |
| SCHEMBL17848942 | 0.70 | PSEN1 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109890820-B | Aminopyrazolopyrimidine compounds as neurotrophin tyrosine kinase receptor inhibitors | 正大天晴药业集团股份有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-108003161-B | Neurotrophic factor tyrosine kinase receptor inhibitors | 正大天晴药业集团股份有限公司 | 2020-10-09 | — | — | CN | disclosed |