Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | ATM | Q13315 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848984 | 0.79 | ALDH1A1 (0.51) | TDP1MAPTL3MBTL1ATMKDM4E | |
| SCHEMBL805035 | 0.78 | L3MBTL1 (0.51) | MAPTL3MBTL1ATMTSHRKDM4E | |
| SCHEMBL2178510 | 0.78 | TDP1 (0.58) | TDP1MAPTL3MBTL1TSHRKDM4E | |
| SCHEMBL789181 | 0.77 | KDM4E (0.51) | MAPTL3MBTL1ATMTSHRKDM4E | |
| SCHEMBL30829251 | 0.77 | TDP1 (0.47) | TDP1MAPTL3MBTL1ATMKDM4E | |
| SCHEMBL13956255 | 0.74 | L3MBTL1 (0.50) | TDP1MAPTL3MBTL1ATMTSHR | |
| SCHEMBL17184396 | 0.73 | NPC1 (0.50) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL2422773 | 0.73 | HDAC1 (0.38) | TDP1KDM4EHRH4GAA | |
| SCHEMBL13966259 | 0.73 | ATM (0.56) | TDP1MAPTL3MBTL1ATMTSHR | |
| SCHEMBL12410057 | 0.73 | TDP1 (0.52) | TDP1MAPTL3MBTL1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100101-A1 | RUTHENIUM-BASED METATHESIS PRE-CATALYST COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016100101-A1 | RUTHENIUM-BASED METATHESIS PRE-CATALYST COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |