Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23148825 | 0.77 | TRPV4 (0.44) | CHRNB2CHRNA4LMNA | |
| SCHEMBL28377948 | 0.74 | LRRK2 (0.41) | LRRK2ATMMAPTCDK1CCNB1 | |
| SCHEMBL8382615 | 0.74 | LRRK2 (0.44) | LRRK2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL725143 | 0.73 | — | — | |
| SCHEMBL22234589 | 0.73 | LRRK2 (0.43) | LRRK2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL364773 | 0.72 | ATM (0.43) | LRRK2ATML3MBTL1MAPTTRPM8 | |
| SCHEMBL11509960 | 0.70 | HPGD (0.44) | LRRK2CHRNB2CHRNA4ATML3MBTL1 | |
| SCHEMBL2476487 | 0.70 | LRRK2 (0.41) | LRRK2ATML3MBTL1MAPTCDK1 | |
| SCHEMBL30610262 | 0.70 | LRRK2 (0.38) | LRRK2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL8576327 | 0.68 | KDM4E (0.37) | LRRK2ATML3MBTL1MAPTCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100101-A1 | RUTHENIUM-BASED METATHESIS PRE-CATALYST COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016100101-A1 | RUTHENIUM-BASED METATHESIS PRE-CATALYST COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |