Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21598414 | 0.79 | AURKA (0.43) | NR4A2SOS2MAPTL3MBTL1GAA | |
| SCHEMBL24196203 | 0.78 | LRRK2 (0.41) | LRRK2POLBALOX5APFEN1CCNA2 | |
| SCHEMBL2375700 | 0.73 | ALOX5AP (0.46) | LRRK2POLBALOX5APFEN1CCNA2 | |
| SCHEMBL27727585 | 0.72 | NOS2 (0.50) | LRRK2POLBALOX5APFEN1CCNA2 | |
| SCHEMBL22488170 | 0.72 | ALDH1A1 (0.42) | MAPK8MAPK9MAPK10ACACBMAPT | |
| SCHEMBL8415149 | 0.71 | NR4A2 (0.36) | POLBNR4A2SOS2GAAG6PD | |
| SCHEMBL22234589 | 0.70 | LRRK2 (0.43) | LRRK2ALOX5APFEN1CCNA2CDK2 | |
| SCHEMBL17848977 | 0.70 | LRRK2 (0.40) | LRRK2ALOX5APFEN1CCNA2CDK2 | |
| SCHEMBL364773 | 0.69 | ATM (0.43) | LRRK2POLBALOX5APFEN1MET | |
| SCHEMBL364666 | 0.68 | LRRK2 (0.35) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370438-A1 | IMIDAZO [1,2A]PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION | Exelixis, Inc. (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010065760-A1 | IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION | EXELIXIS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |