SCHEMBL1785

SCHEMBL1785

Cc1noc(-c2ccc(Br)cc2)c1C=CC(C)(C)CO

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
MMP9 P14780 1/20 0.33
BRD4 O60885 2/20 0.32
BRD2 P25440 2/20 0.32
BRD3 Q15059 2/20 0.32
PPARA Q07869 2/20 0.31
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
EDNRB P24530 2/20 0.31
EDNRA P25101 2/20 0.31
NPC1 O15118 1/20 0.30
STAT1 P42224 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2369 0.86 CYP1A2 (0.35) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL1173 0.81 CYP1A2 (0.39) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL2110 0.79 TDP1 (0.37) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL2323 0.77 CYP1A2 (0.36) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL7129 0.77 BRD4 (0.36) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL18746108 0.77 CYP1A2 (0.40) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL4359 0.76 EDNRB (0.37) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL1921 0.73 BRD4 (0.41) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL1575 0.72 IP6K1 (0.45) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL2153 0.72 CYP1A2 (0.41) CYP1A2CYP3A4CYP2C9CYP2C19TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
EP-2483253-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041729-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed