SCHEMBL2369

SCHEMBL2369

Cc1noc(-c2ccc(Br)cc2)c1C=CC(F)(F)CO

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MLYCD O95822 1/20 0.33
TARBP2 Q15633 1/20 0.31
MAPT P10636 2/20 0.31
TP53 P04637 1/20 0.31
CACNA1F O60840 1/20 0.31
ABCB1 P08183 1/20 0.31
CACNA1D Q01668 1/20 0.31
CACNA1S Q13698 1/20 0.31
CACNA1C Q13936 1/20 0.31
EDNRB P24530 2/20 0.30
EDNRA P25101 2/20 0.30
MMP9 P14780 1/20 0.30
HTT P42858 1/20 0.30
NPC1 O15118 1/20 0.30
STAT1 P42224 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1785 0.86 CYP1A2 (0.36) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL1173 0.80 CYP1A2 (0.39) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL2110 0.78 TDP1 (0.37) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL7129 0.76 BRD4 (0.36) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL2323 0.76 CYP1A2 (0.36) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL18746108 0.76 CYP1A2 (0.40) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL4359 0.75 EDNRB (0.37) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL1633 0.72 NR1H4 (0.33) MAPTNPC1SMN1; SMN2KDM4EALDH1A1
SCHEMBL1921 0.72 BRD4 (0.41) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL1294 0.71 MEN1 (0.34) CYP1A2CYP2C9MAPTNPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
EP-2483253-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041729-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed