Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.53 |
| ▸ | TACR3 | P29371 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111176 | 0.88 | P2RX7 (0.68) | P2RX7TACR3KCNH2 | |
| SCHEMBL107757 | 0.81 | P2RX7 (0.66) | P2RX7TACR3 | |
| SCHEMBL110280 | 0.80 | P2RX7 (0.56) | P2RX7TACR3KCNH2 | |
| SCHEMBL17850273 | 0.79 | P2RX7 (0.54) | P2RX7 | |
| SCHEMBL108944 | 0.79 | P2RX7 (0.68) | P2RX7TACR3 | |
| SCHEMBL108491 | 0.78 | P2RX7 (0.67) | P2RX7 | |
| SCHEMBL107226 | 0.78 | P2RX7 (0.57) | P2RX7 | |
| SCHEMBL107638 | 0.77 | TACR3 (0.63) | P2RX7TACR3KCNH2 | |
| SCHEMBL17850239 | 0.76 | P2RX7 (0.79) | P2RX7 | |
| SCHEMBL17836823 | 0.75 | TACR3 (0.71) | P2RX7TACR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-B1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LTD (GB) | 2016-06-22 | — | — | EP | disclosed |