Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.34 |
| ▸ | KDM6B | O15054 | 4/20 | 0.34 |
| ▸ | KDM5C | P41229 | 4/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.34 |
| ▸ | KDM4A | O75164 | 3/20 | 0.34 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194963 | 0.85 | FLT3 (0.41) | EGFRBRD4FLT3KDM2AKDM6B | |
| SCHEMBL10194810 | 0.82 | VNN1 (0.39) | EGFRKDM2AKDM6BKDM5CKDM4C | |
| SCHEMBL10194868 | 0.76 | ACKR3 (0.39) | KMT2AKDM4E | |
| SCHEMBL17850433 | 0.76 | MAPK14 (0.36) | EGFRFLT3MAPK14 | |
| SCHEMBL10195593 | 0.75 | KMT2A (0.52) | BRD4PIM1KMT2AGRM3 | |
| SCHEMBL10194766 | 0.72 | MAPK10 (0.42) | EGFRFLT3KDM2AKDM6BKDM5C | |
| SCHEMBL15317702 | 0.72 | KMT2A (0.48) | BRD4PIM1KMT2A | |
| SCHEMBL10195560 | 0.72 | FLT3 (0.41) | EGFRFLT3KDM2AKDM6BKDM5C | |
| SCHEMBL10194775 | 0.71 | FLT3 (0.44) | EGFRFLT3KDM2AKDM6BKDM5C | |
| SCHEMBL10195583 | 0.70 | KMT2A (0.46) | FLT3KMT2AKDM4EGRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |