Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194854 | 0.83 | MAPK10 (0.42) | MAPK14LRRK2ROCK2JAK2PIK3CA | |
| SCHEMBL10194810 | 0.82 | VNN1 (0.39) | MAPK14JAK2MGLLEGFR | |
| SCHEMBL10194707 | 0.77 | MAPK10 (0.41) | MAPK14ACKR3LRRK2ROCK2JAK2 | |
| SCHEMBL17850418 | 0.76 | EGFR (0.36) | MAPK14EGFRFLT3 | |
| SCHEMBL10194699 | 0.73 | FLT3 (0.39) | ACKR3LRRK2MAPK10FLT3 | |
| SCHEMBL10194859 | 0.72 | FLT3 (0.42) | LRRK2ROCK2JAK2PIK3CALCK | |
| SCHEMBL10194868 | 0.72 | ACKR3 (0.39) | ACKR3JAK2 | |
| SCHEMBL10195456 | 0.71 | GPR119 (0.37) | LRRK2MAPK10 | |
| SCHEMBL10194993 | 0.70 | FLT3 (0.46) | LRRK2JAK2MAPK10FLT3 | |
| SCHEMBL10194775 | 0.68 | FLT3 (0.44) | LRRK2ROCK2JAK2LCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |