Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194756 | 0.88 | L3MBTL3 (0.45) | MAPK14MAPK10MAPK8FLT3RBP4 | |
| SCHEMBL10194757 | 0.85 | JAK2 (0.49) | MAPK14MAPK10MAPK8FLT3ABL1 | |
| SCHEMBL19145802 | 0.80 | KDR (0.43) | MAPK14FLT3MGLLALDH1A1HPGD | |
| SCHEMBL10194758 | 0.79 | ATR (0.46) | MAPK10MAPK8FLT3 | |
| SCHEMBL10194762 | 0.78 | ABL1 (0.45) | MAPK14MAPK10FLT3ABL1BCR | |
| SCHEMBL9952532 | 0.78 | L3MBTL3 (0.45) | AXLMAPK10MAPK8FLT3ABL1 | |
| SCHEMBL10194890 | 0.78 | AXL (0.50) | AXLMAPK10FLT3 | |
| SCHEMBL9953219 | 0.78 | MGLL (0.44) | AXLMAPK10MAPK8FLT3PAK1 | |
| SCHEMBL10194974 | 0.77 | IDO1 (0.45) | AXLMAPK10MAPK8FLT3PAK1 | |
| SCHEMBL10194781 | 0.77 | JAK2 (0.49) | MAPK10FLT3ABL1BCRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |