Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850422 | 0.82 | MET (0.39) | METPOLBMEN1KMT2A | |
| SCHEMBL17850416 | 0.82 | MEN1 (0.39) | METPOLBKDM4ECYP3A4CYP2C9 | |
| SCHEMBL10194889 | 0.77 | JAK2 (0.42) | METPOLBKDM4ECYP3A4CYP2C9 | |
| SCHEMBL10194922 | 0.69 | MET (0.39) | MET | |
| SCHEMBL10194887 | 0.69 | JAK2 (0.41) | MET | |
| SCHEMBL10194788 | 0.69 | JAK2 (0.42) | METPOLBKDM4ECYP3A4CYP2C9 | |
| SCHEMBL10194883 | 0.66 | MET (0.41) | METMIF | |
| SCHEMBL17850389 | 0.66 | MET (0.44) | MET | |
| SCHEMBL30398818 | 0.66 | PARP1 (0.57) | — | |
| SCHEMBL10194916 | 0.65 | IDO1 (0.42) | CYP3A4CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |