Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9290603 | 0.79 | POLB (0.66) | TSHRCA1CA2CA4CA9 | |
| SCHEMBL9891787 | 0.75 | KDM4E (0.70) | TSHRCA1CA2CA4CA9 | |
| SCHEMBL11614784 | 0.74 | FFAR2 (0.60) | TSHRCA1CA2CA4CA9 | |
| SCHEMBL11049891 | 0.73 | CA1 (1.00) | CA1CA2CA4CA9SMN1; SMN2 | |
| SCHEMBL21325843 | 0.73 | TSHR (0.55) | TSHRCA1CA2CA4CA9 | |
| SCHEMBL17850506 | 0.73 | CA1 (0.72) | TSHRCA1CA2CA4CA9 | |
| SCHEMBL18552813 | 0.73 | TSHR (0.55) | TSHRCA1CA2CA4CA9 | |
| SCHEMBL12768097 | 0.73 | TSHR (0.84) | TSHRSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9891908 | 0.71 | NPC1 (0.63) | TSHRSMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL11617965 | 0.71 | TSHR (0.54) | TSHRCA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643299-B1 | BIPYRIDINE SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES OR CONDITIONS | NOSCIRA SA (ES) | 2016-06-22 | — | — | EP | disclosed |