Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | GCKR | Q14397 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17853463 | 1.00 | MAP2K4 (0.38) | MAP2K4MAP2K7KCNH2ALDH1A1UCHL1 | |
| SCHEMBL17853849 | 1.00 | MAP2K4 (0.38) | MAP2K4MAP2K7KCNH2ALDH1A1UCHL1 | |
| SCHEMBL16378447 | 0.87 | MAP2K4 (0.41) | MAP2K4MAP2K7KCNH2ALDH1A1PTGS1 | |
| SCHEMBL16335157 | 0.87 | MAP2K4 (0.41) | MAP2K4MAP2K7KCNH2ALDH1A1PTGS1 | |
| SCHEMBL16378424 | 0.87 | MAP2K4 (0.41) | MAP2K4MAP2K7KCNH2ALDH1A1PTGS1 | |
| SCHEMBL19196183 | 0.85 | MAP2K4 (0.44) | MAP2K4MAP2K7KCNH2ALDH1A1CNR1 | |
| SCHEMBL16378419 | 0.83 | PTGDR2 (0.39) | UCHL1USP30KDM4ERECQLSMN1; SMN2 | |
| SCHEMBL16378434 | 0.83 | PTGDR2 (0.39) | UCHL1USP30KDM4ERECQLSMN1; SMN2 | |
| SCHEMBL16378442 | 0.83 | PTGDR2 (0.39) | UCHL1USP30KDM4ERECQLSMN1; SMN2 | |
| SCHEMBL16335530 | 0.77 | MAP2K4 (0.46) | MAP2K4MAP2K7KCNH2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834414-B2 | 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use | Modern Biosciences Limited (GB) | 2023-12-05 | — | — | US | disclosed |
| US-11834414-B2 | 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use | Modern Biosciences Limited (GB) | 2023-12-05 | — | — | US | disclosed |
| EP-3262028-B1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(-4HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | PIMCO 2664 LTD (GB) | 2021-10-27 | — | — | EP | disclosed |
| EP-3262028-B1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(-4HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | PIMCO 2664 LTD (GB) | 2021-10-27 | — | — | EP | disclosed |
| CN-107108508-B | N- (4-hydroxy-4-methyl-cyclohexyl) -4-phenyl-benzenesulfonamide and N- (4-hydroxy-4-methyl-cyclohexyl) -4- (2-pyridyl) -benzenesulfonamide compounds and their therapeutic use | 皮姆科2664有限公司 | 2020-09-01 | — | — | CN | disclosed |
| WO-2020035560-A1 | 1-METHYL-4-[(4-PHENYLPHENYL)SULFONYLMETHYL]CYCLOHEXYANOL AND 1-METHYL-4-[[4-(2-PYRIDYL)PHENYL]SULFONYLMETHYL]CYCLOHEXANOL COMPOUNDS AND THEIR THERAPEUTIC USE | Modern Biosciences Limited (GB) | 2020-02-20 | — | — | WO | disclosed |
| US-20180297955-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | PIMCO 2664 LIMITED (GB) | 2018-10-18 | — | — | US | disclosed |
| US-10005733-B2 | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use | PIMCO 2664 LIMITED (GB) | 2018-06-26 | — | — | US | disclosed |
| US-10005733-B2 | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use | PIMCO 2664 LIMITED (GB) | 2018-06-26 | — | — | US | disclosed |
| US-10005733-B2 | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use | PIMCO 2664 LIMITED (GB) | 2018-06-26 | — | — | US | disclosed |
| US-20170349551-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | PIMCO 2664 LIMITED (GB) | 2017-12-07 | — | — | US | disclosed |
| US-20170349551-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | PIMCO 2664 LIMITED (GB) | 2017-12-07 | — | — | US | disclosed |
| US-20170349551-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | PIMCO 2664 LIMITED (GB) | 2017-12-07 | — | — | US | disclosed |
| WO-2016097001-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | PIMCO 2664 LIMITED (GB) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180297955-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | BRCA1, MYLK2, SOST | MAP2K4 1763/4885MAP2K7 2356/4885KCNH2 4163/4885 |
| US-20170349551-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDE AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)-BENZENESULFONAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | BRCA1, MYLK2, SOST | MAP2K4 1763/4885MAP2K7 2356/4885KCNH2 4163/4885 |
| US-11834414-B2 | 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use | MALT1, BCL3, MCL1 | MAP2K4 2634/4885MAP2K7 3166/4885KCNH2 3222/4885 |
| US-10005733-B2 | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use | BRCA1, MYLK2, SOST | MAP2K4 1775/4885MAP2K7 2358/4885KCNH2 4170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.