Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16335157 | 0.90 | MAP2K4 (0.41) | MAP2K4MAP2K7SMOLMNAALDH1A1 | |
| SCHEMBL16378418 | 0.90 | MAP2K4 (0.46) | MAP2K4MAP2K7KMT2ATDP1MAPT | |
| SCHEMBL16378424 | 0.90 | MAP2K4 (0.41) | MAP2K4MAP2K7SMOLMNAALDH1A1 | |
| SCHEMBL16378447 | 0.90 | MAP2K4 (0.41) | MAP2K4MAP2K7SMOLMNAALDH1A1 | |
| SCHEMBL16335531 | 0.90 | MAP2K4 (0.46) | MAP2K4MAP2K7KMT2ATDP1MAPT | |
| SCHEMBL19156761 | 0.90 | MAP2K4 (0.46) | MAP2K4MAP2K7KMT2ATDP1MAPT | |
| SCHEMBL16335530 | 0.90 | MAP2K4 (0.46) | MAP2K4MAP2K7KMT2ATDP1MAPT | |
| SCHEMBL17853849 | 0.85 | MAP2K4 (0.38) | MAP2K4MAP2K7ALDH1A1KCNH2CNR1 | |
| SCHEMBL17853456 | 0.85 | MAP2K4 (0.38) | MAP2K4MAP2K7ALDH1A1KCNH2CNR1 | |
| SCHEMBL17853463 | 0.85 | MAP2K4 (0.38) | MAP2K4MAP2K7ALDH1A1KCNH2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217881-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDES AND N-(4- HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)BENZENESULFONAMIDES AND THEIR THERAPEUTIC USE | PIMCO 2664 LIMITED (GB) | 2017-08-03 | — | — | US | disclosed |
| US-20170217881-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDES AND N-(4- HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)BENZENESULFONAMIDES AND THEIR THERAPEUTIC USE | PIMCO 2664 LIMITED (GB) | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217881-A1 | N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDES AND N-(4- HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)BENZENESULFONAMIDES AND THEIR THERAPEUTIC USE | BRCA1, TPMT, SOST | MAP2K4 1966/4885MAP2K7 2772/4885KMT2A 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.