Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.65 |
| ▸ | PIK3C2B | O00750 | 17/20 | 0.65 |
| ▸ | MTOR | P42345 | 14/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19760618 | 0.92 | PIK3CD (0.64) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB | |
| SCHEMBL17857180 | 0.89 | PIK3C2B (0.62) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB | |
| SCHEMBL17857142 | 0.87 | PIK3CD (0.54) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB | |
| SCHEMBL19760620 | 0.86 | PIK3CD (0.60) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB | |
| SCHEMBL19760561 | 0.86 | PIK3CD (0.66) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB | |
| SCHEMBL17858457 | 0.83 | PIK3C2B (0.69) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB | |
| SCHEMBL17857378 | 0.82 | PIK3CD (0.81) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB | |
| SCHEMBL21386264 | 0.82 | PIK3C2B (0.57) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB | |
| SCHEMBL19913073 | 0.81 | PIK3C2B (0.63) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB | |
| SCHEMBL17857136 | 0.80 | PIK3C2B (0.61) | PIK3CDPIK3C2BMTORPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180002336-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-01-04 | — | — | US | disclosed |
| WO-2016097347-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002336-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS | PIK3CB, PIK3CD, PIK3CA | PIK3CD 2/4885PIK3C2B 6/4885MTOR 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.