Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.50 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.50 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PRF1 | P14222 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17858621 | 0.84 | MEN1 (0.60) | SLC22A12KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL13539327 | 0.84 | SLC22A12 (0.60) | SLC22A12KMT2AMEN1PIK3CBTSHR | |
| SCHEMBL22914714 | 0.83 | PGR (0.50) | KMT2AMEN1PGRLMNASMN1; SMN2 | |
| SCHEMBL19728992 | 0.83 | PIK3CB (0.50) | SLC22A12KMT2APGRLMNASMN1; SMN2 | |
| SCHEMBL13807498 | 0.81 | PGR (0.68) | KMT2AMEN1PGRLMNASMN1; SMN2 | |
| SCHEMBL21083146 | 0.81 | PRF1 (0.47) | KMT2APGRLMNASMN1; SMN2PRF1 | |
| SCHEMBL16020319 | 0.80 | MEN1 (0.62) | KMT2AMEN1TSHRALDH1A1POLB | |
| SCHEMBL23565665 | 0.80 | KMT2A (0.71) | KMT2AMEN1PGRLMNASMN1; SMN2 | |
| SCHEMBL11918322 | 0.78 | PIK3CB (0.64) | SLC22A12PRF1PIK3CB | |
| SCHEMBL9517147 | 0.78 | PGR (0.54) | SLC22A12KMT2AMEN1PGRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170360788-A1 | SMALL MOLECULE INHIBITORS OF EGFR AND PI3K | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2017-12-21 | — | — | US | disclosed |
| WO-2016100347-A2 | SMALL MOLECULE INHIBITORS OF EGFR AND PI3K | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170360788-A1 | SMALL MOLECULE INHIBITORS OF EGFR AND PI3K | EGFR, ERBB2, ERBB3 | SLC22A12 2643/4885KMT2A 2786/4885MEN1 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.