Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 7/20 | 0.74 |
| ▸ | RARA | P10276 | 6/20 | 0.74 |
| ▸ | RARB | P10826 | 6/20 | 0.74 |
| ▸ | RARG | P13631 | 6/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | PGR | P06401 | 1/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.74 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.74 |
| ▸ | BLVRB | P30043 | 1/20 | 0.74 |
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13027032 | 0.88 | CYP26A1 (0.76) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL1615110 | 0.85 | RARA (0.80) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL8461840 | 0.85 | CYP26A1 (0.80) | CYP26A1RARARARBRARGCYP3A4 | |
| Tamibarotene SCHEMBL36207 | 0.85 | RARB (1.00) | CYP26A1RARARARBRARGCYP3A4 | |
| Tamibarotene SCHEMBL29373818 | 0.85 | RARB (1.00) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL19560600 | 0.85 | RARA (0.80) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL13999715 | 0.85 | CYP26A1 (0.80) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL2896779 | 0.84 | CYP26A1 (0.77) | CYP26A1RARARARBRARGCYP3A4 | |
| Tamibarotene SCHEMBL21055743 | 0.84 | RARB (0.97) | CYP26A1RARARARBRARGCYP3A4 | |
| SCHEMBL8461304 | 0.84 | RARA (0.78) | CYP26A1RARARARBRARGCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9452220-B2 | Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2016-09-27 | — | — | US | disclosed |
| US-20160175453-A1 | COUPLING COMPOUNDS OF NSAID ANTI-INFLAMMATORY AND ANALGESIC DRUGS AND EGFR KINASE INHIBITORS, SYNTHESIS METHODS AND APPLICATIONS THEREOF | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160175453-A1 | COUPLING COMPOUNDS OF NSAID ANTI-INFLAMMATORY AND ANALGESIC DRUGS AND EGFR KINASE INHIBITORS, SYNTHESIS METHODS AND APPLICATIONS THEREOF | EGFR, CHUK, ERBB2 | CYP26A1 695/4885RARA 2171/4885RARB 1926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.