Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPC | P11150 | 5/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | NPC1L1 | Q9UHC9 | 6/20 | 0.37 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | RORB | Q92753 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17859500 | 0.91 | PAK4 (0.38) | LIPCRORCCRBN | |
| SCHEMBL19742285 | 0.89 | LIPC (0.41) | LIPCRORCLIPGERN1 | |
| SCHEMBL17859309 | 0.83 | LIPC (0.41) | LIPCHDAC4LIPGERN1 | |
| SCHEMBL19742270 | 0.80 | PAK4 (0.40) | LIPCRORC | |
| SCHEMBL19079582 | 0.79 | PAK4 (0.48) | LIPCHDAC4NPC1L1PDE3BPDE3A | |
| SCHEMBL17859239 | 0.79 | PAK4 (0.59) | LIPCRORCLIPGERN1 | |
| SCHEMBL17859532 | 0.78 | PAK4 (0.41) | HDAC4RORC | |
| SCHEMBL19742286 | 0.76 | LIPC (0.38) | LIPCHDAC4ERN1 | |
| SCHEMBL18541397 | 0.76 | PAK4 (0.39) | LIPCHDAC4NPC1L1LIPG | |
| SCHEMBL17859366 | 0.75 | PAK4 (0.46) | LIPCHDAC4NPC1L1RORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100515-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2016-06-23 | — | — | WO | disclosed |