Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | LIPC | P11150 | 2/20 | 0.37 |
| ▸ | NPC1L1 | Q9UHC9 | 7/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | RORB | Q92753 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19742290 | 0.88 | PAK4 (0.49) | PAK4NAMPTPAK1LIPCHDAC1 | |
| SCHEMBL16379647 | 0.84 | PAK4 (0.63) | PAK4NAMPTPAK1GRM2LIPC | |
| SCHEMBL19753621 | 0.84 | PAK4 (0.47) | PAK4NAMPTPAK1LIPCHDAC1 | |
| SCHEMBL18541372 | 0.83 | PAK4 (0.46) | PAK4NAMPTPAK1GRM2LIPC | |
| SCHEMBL18541435 | 0.82 | PAK4 (0.48) | PAK4NAMPTPAK1GRM2LIPC | |
| SCHEMBL18541399 | 0.81 | PAK4 (0.49) | PAK4NAMPTPAK1GRM2LIPC | |
| SCHEMBL19078998 | 0.80 | NAMPT (0.58) | PAK4NAMPTPAK1LIPCHDAC1 | |
| SCHEMBL18542169 | 0.80 | PAK4 (0.46) | PAK4NAMPTPAK1GRM2LIPC | |
| SCHEMBL19079065 | 0.79 | NAMPT (0.46) | PAK4NAMPTPAK1HDAC2HDAC1 | |
| SCHEMBL18329014 | 0.79 | PAK4 (0.57) | PAK4NAMPTPAK1GRM2LIPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100515-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2016-06-23 | — | — | WO | disclosed |