Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL1783897 | 0.82 | TSHR (0.54) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL28908043 | 0.81 | DAO (0.48) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL1783840 | 0.80 | DAO (0.47) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL9856616 | 0.80 | TSHR (0.47) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL1334580 | 0.80 | TSHR (0.47) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL11963082 | 0.80 | DAO (0.47) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL1784503 | 0.79 | TSHR (0.50) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL11228092 | 0.78 | TSHR (0.58) | TSHRDAONAPRTCES2CES1 | |
| Benzoic Acid SCHEMBL5085502 | 0.78 | TSHR (0.58) | TSHRDAONAPRTCES2CES1 | |
| Terephthalic Acid SCHEMBL28416525 | 0.78 | MEN1 (0.47) | TSHRSRD5A2RXRARXRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239636-A1 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-10-27 | — | — | US | claimed |
| EP-3486263-A2 | SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE | W.R. Grace & CO. - CONN. (US) | 2019-05-22 | — | — | EP | disclosed |
| EP-2185600-B1 | SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE | GRACE W R & CO (US) | 2018-10-31 | — | — | EP | disclosed |
| US-9796796-B2 | Self-limiting catalyst composition with No silane | W. R. GRACE & CO.-CONN. (US) | 2017-10-24 | — | — | US | disclosed |
| EP-1666505-B1 | CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF | CHINA PETROLEUM & CHEMICAL (CN) | 2016-03-23 | — | — | EP | disclosed |
| CN-103087222-A | Olefin polymerization catalyst, process for producing olefin polymer, polypropylene resin composition and article comprising the same | SUMITOMO CHEMICAL CO | 2013-05-08 | — | — | CN | disclosed |
| US-20130109789-A1 | OLEFIN POLYMERIZATION CATALYST, PROCESS FOR PRODUCING OLEFIN POLYMER, POLYPROPYLENE RESIN COMPOSITION AND ARTICLE COMPRISING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-05-02 | — | — | US | disclosed |
| US-20110124491-A1 | Self-Limiting Catalyst Composition with No Silane | W. R. GRACE & CO.-CONN. | 2011-05-26 | — | — | US | disclosed |
| CN-101565475-A | Catalyst component and catalyst thereof for olefinic polymerization | CHINA PETROLEUM & CHEMICAL (CN) | 2009-10-28 | — | — | CN | disclosed |
| US-7388061-B2 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-06-17 | — | — | US | disclosed |
| US-7332455-B2 | Catalyst component and catalyst for olefin polymerization as well as use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2008-02-19 | — | — | US | disclosed |
| EP-1666505-A1 | CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF | China Petroleum & Chemical Corporation (CN) | 2006-06-07 | — | — | EP | disclosed |
| US-20050239636-A1 | Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof | CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-10-27 | — | — | US | disclosed |
| US-20050119427-A1 | Catalyst component and catalyst for olefin polymerization as well as use thereof | BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) | 2005-06-02 | — | — | US | disclosed |
| CN-1446197-A | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | CN | disclosed |