Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HPN | P05981 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | NPC1L1 | Q9UHC9 | 4/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 4/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18541374 | 0.94 | PAK4 (0.40) | PAK4NAMPTPAK1HPNNPC1L1 | |
| SCHEMBL18541386 | 0.88 | PAK4 (0.37) | PAK4NAMPTPAK1HPNNPC1L1 | |
| SCHEMBL18529784 | 0.88 | PAK4 (0.49) | PAK4NAMPTPAK1HDAC1HDAC3 | |
| SCHEMBL17859366 | 0.83 | PAK4 (0.46) | PAK4NAMPTPAK1GRM2HDAC2 | |
| SCHEMBL16379647 | 0.83 | PAK4 (0.63) | PAK4NAMPTPAK1GRM2HDAC2 | |
| SCHEMBL18529794 | 0.82 | PAK4 (0.48) | PAK4NAMPTPAK1GRM2HDAC1 | |
| SCHEMBL18541399 | 0.80 | PAK4 (0.49) | PAK4NAMPTPAK1GRM2HDAC2 | |
| SCHEMBL18542169 | 0.78 | PAK4 (0.46) | PAK4NAMPTPAK1GRM2HDAC2 | |
| SCHEMBL17859408 | 0.78 | PAK4 (0.41) | PAK4NAMPTPAK1 | |
| SCHEMBL18329014 | 0.78 | PAK4 (0.57) | PAK4NAMPTPAK1GRM2HPN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017031204-A1 | CYCLOPROPYLDERIVATIVES AND THEIR USE AS KINASE INHIBITORS | Karyopharm Therapeutics Inc. (US) | 2017-02-23 | — | — | WO | disclosed |