Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 3/20 | 0.52 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.45 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | APOB | P04114 | 9/20 | 0.34 |
| ▸ | MTTP | P55157 | 8/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860437 | 0.88 | PAX8 (0.53) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL17860468 | 0.86 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL16980367 | 0.86 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL16984262 | 0.86 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL17860402 | 0.85 | PAX8 (0.62) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL17860356 | 0.83 | PAX8 (0.44) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL17860352 | 0.82 | PAX8 (0.46) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL16980396 | 0.81 | PAX8 (0.66) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL17860300 | 0.81 | PAX8 (0.60) | PAX8PLCG1PLCB3CASP6APOB | |
| SCHEMBL17860362 | 0.80 | PAX8 (0.69) | PAX8PLCG1PLCB3CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |