Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 4/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.42 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860352 | 0.85 | PAX8 (0.46) | PAX8PLCG1PLCB3CASP6GRM7 | |
| SCHEMBL17860344 | 0.84 | KDM4E (0.33) | GRM7ACHEKDM4ERECQLCAPN1 | |
| SCHEMBL17860355 | 0.83 | PAX8 (0.52) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL17860400 | 0.81 | PAX8 (0.56) | PAX8PLCG1PLCB3CASP6GRM7 | |
| SCHEMBL17860385 | 0.79 | PAX8 (0.57) | PAX8PLCG1PLCB3CASP6GRM7 | |
| SCHEMBL17860302 | 0.78 | PAX8 (0.55) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL17860392 | 0.77 | PAX8 (0.58) | PAX8PLCG1PLCB3CASP6GRM7 | |
| SCHEMBL17860390 | 0.77 | PAX8 (0.58) | PAX8PLCG1PLCB3CASP6GRM7 | |
| SCHEMBL17860357 | 0.75 | PAX8 (0.56) | PAX8PLCG1PLCB3CASP6GRM7 | |
| SCHEMBL17860358 | 0.75 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |