Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 3/20 | 0.63 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.58 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860317 | 0.93 | PAX8 (0.64) | PAX8PLCG1PLCB3CASP6ALDH1A1 | |
| SCHEMBL17860360 | 0.91 | PAX8 (0.67) | PAX8PLCG1PLCB3CASP6RAB9A | |
| SCHEMBL17860371 | 0.90 | PAX8 (0.67) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL17860358 | 0.90 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6ALDH1A1 | |
| SCHEMBL17860454 | 0.90 | PAX8 (0.61) | PAX8PLCG1PLCB3CASP6ALDH1A1 | |
| SCHEMBL17860462 | 0.89 | PAX8 (0.71) | PAX8PLCG1PLCB3CASP6RAB9A | |
| SCHEMBL17860363 | 0.88 | PAX8 (0.68) | PAX8PLCG1PLCB3CASP6ALDH1A1 | |
| SCHEMBL16980367 | 0.87 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6TP53 | |
| SCHEMBL16984262 | 0.87 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6TP53 | |
| SCHEMBL17860468 | 0.87 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |