Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 5/20 | 0.67 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.63 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.63 |
| ▸ | CASP6 | P55212 | 1/20 | 0.57 |
| ▸ | HTR1F | P30939 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860363 | 0.94 | PAX8 (0.68) | PAX8PLCG1PLCB3CASP6MAPK14 | |
| SCHEMBL16980367 | 0.93 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL17860468 | 0.93 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL16984262 | 0.93 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL17860462 | 0.93 | PAX8 (0.71) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL17860453 | 0.93 | PAX8 (0.73) | PAX8PLCG1PLCB3CASP6 | |
| SCHEMBL16980396 | 0.92 | PAX8 (0.66) | PAX8PLCG1PLCB3CASP6HTR1F | |
| SCHEMBL17860394 | 0.92 | PAX8 (0.65) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL17860368 | 0.91 | PAX8 (0.64) | PAX8PLCG1PLCB3CASP6ROCK2 | |
| SCHEMBL17860365 | 0.90 | PAX8 (0.63) | PAX8PLCG1PLCB3CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |